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Pursuant to the creation of the College of Science by the Board of Regents in its962nd meeting on 26 October 1983, there is hereby established the College of Science Library (CSLIB) under U.P. Administrative Order No. 62 (series of 1987). Thru the initiative of its first dean, Dr. Roger Posadas, the library was inaugurated on 24 June 1987 and from then on, the library perform its function in assisting the college in its basic functions of instruction, research and extension services.

CS library facadeFrom 1987 to 1994, the CSLIB operated as a traditional library with a collection composed mainly of print materials transferred from the Science Section of the U.P. Main Library and the National Science Research Institute. For access to information, it made use of the card catalog and printed abstracts and indexes. Interlibrary loan was limited to libraries within the University of the Philippines System and among neighboring university libraries.

In 1992, it became the lead institution of the DOST-ESEP Library Network headed by its former Head Librarian, Mrs. Lourdes T. David. This marked the beginning of its automation project by acquiring a library integrated software called "TINLIB". In 1993, it acquired a grant from UNESCO that supports further the library's modernization infrastructure projects.

Until recently, the library celebrated its 25th year anniversary by acquiring a more spacious building from the old CSLAB converted to CSLIB. The renovation is part of the library improvement program which aims to provide additional facilities and services to its patrons. Moreover, the library now extends it's services by establishing institute libraries as user needs become increasingly diverse. This unique set-up will eventually help address the personalization and customization of services to meet the individual working requirements.